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1-Acetyl-4-(4-hydroxyphenyl)piperazine is a ketoconazole intermediate. This intermediate is synthesized from diethanolamine as a starting material by chlorination, cyclization and acylation. The target compound synthesized by this process route has better total product yield than the current process, and the process is simple in operation and low in production cost.
Its melting point is 178-180 ° C, and it can be used for the synthesis of the drug ketoconazole, itraconazole.
Category: Intermediates/Pharmaceutical intermediates
CAS NO: 67914-60-7
EC NO: 267-744-8
Molecular Formula: C12H16N2O2
Molecular Weight: 220.2676
Specification: in-house
Synonyms:
4-(4-acetylpiperazin-4-yl)phenol; 1-Acetyl-4-(4hydroxyphenyl)piperazine;
4-(4-Acetyl-1-piperaino)phenol; Tetraethoxy C methyl propane;
1-[4-(4-hydroxyphenyl)piperazin-1-yl]ethanone; 4-(1-Acetylpiperazin-4-yl)phenol;
Molecular Structure:
